Endocrine Abstracts

Introduction: Prenatal and perinatal food manipulation might be related with bone quality in offspring of Wistar rats. This study aimed to assess the impact of different dietary patterns provided before delivery to the mothers on the skeletal characteristics of newborn rats and the levels of insulin.Materials and methods: We randomized 67 timed-pregnant rats into control diet (CD), high-fat (FD) and food-restricted (FR) on the 12th day of gestation. The ...

Introduction: Bile acid (BA)-feeding and genetic manipulation of BA receptors affect glucose tolerance in rodent pregnancy. In non-pregnant individuals, serum BA profiles depend on BMI and ethnicity. The interaction between serum BAs, ethnicity, and BMI in gestational diabetes mellitus (GDM) remains poorly understood.Methods: Fasted serum samples were collected between 23-31 weeks’ gestation. Experimental groups: lean or obese women of European (EU)...

Objectives: This study aimed to assess the results of different perinatal nutritional patterns on skeletal development and insulin regulation of one-year-old Wistar rats.Methods: Three different diet regiments [Control Diet, (CD), food-restricted (FR), or fat-fed (FF)] were randomly provided to sixty-seven primigravid rats from the 12th till the 21st gestational date when they gave birth and throughout the 25-day lactation period. According to...